Genetics

Displaying 1 - 50 of 315

A 122.5-kilobase Deletion of the P Gene Underlies the High Prevalence of Oculocutaneous Albinism Type 2 in the Navajo Population

Articles » Scholarly, peer reviewed
Author/Creator
Zanhua Yi
Nanibaa' Garrison
Orit Cohen-Barak
Tatiana M. Karafet
Richard A. King
Robert P. Erickson
Michael F. Hammer
Murray H. Brilliant
American Journal of Human Genetics, vol. 72, no. 1, January 2003, pp. 62-72
Description
Study indicates an absence of a specific gene contributes to albinism.
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-6A Promoter Variant of Angiotensinogen and Blood Pressure Variation in Canadian Oji-Cree

Articles » Scholarly, peer reviewed
Author/Creator
R. A. Hegele
S. B. Harris
A. J. Hanley
F. Sun
P. W. Connelly
B. Zinman
Journal of Human Genetics, vol. 43, no. 1, 1998, pp. 37-41
Description
Study found that while the presence of the AGT -6A variant tended to be associated with higher systolic blood pressure, it was not found to be significant in this population of Canadian Oji-Cree.
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Absence of Association Between Genetic Variation in the LIPC Gene Promoter and Plasma Lipoproteins in Three Canadian Populations

Articles » Scholarly, peer reviewed
Author/Creator
Robert A. Hegele
Stewart B. Harris
J. Howard Brunt
T. Kue Young
Anthony J. G. Hanley
Bernard Zinman
Philip W. Connelly
Atherosclerosis, vol. 146, no. 1, September 1999, pp. 153-160
Description
Findings of testing on 3 distinct populations, Hutterites, Oji-Cree and Keewatin Inuit, indicate there's no consistent relationship between the population mean plasma HDL cholesterol concentration and then population LIPC-480T frequency.
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Absence of Association between Genetic Variation of the β 3-Adrenergic Receptor and Metabolic Phenotypes in Oji-Cree

Alternate Title
Absence of Association between Genetic Variation of the Beta 3-Adrenergic Receptor and Metabolic Phenotypes in Oji-Cree
Articles » Scholarly, peer reviewed
Author/Creator
Robert A. Hegele
Steward B. Harris
Anthony J. Hanley
Husian Azouz
Philip W. Connelly
Bernard Zinman
Diabetes Care, vol. 21, no. 5, May 1998, pp. 851-854
Description
Study undertaken to determine if there is a relationship between ADRB3 R64 allele and obesity and type 2 diabetes in a sample of Aboriginal Canadians.
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Access and Benefits Sharing of Genetic Resources and Associated Traditional Knowledge in Northern Canada: Understanding the Legal Environment and Creating Effective Research Agreements

Alternate Title
Proceedings of the 15th International Congress on Circumpolar Health
Articles » Scholarly, peer reviewed
Author/Creator
Janis Geary
Cynthia G. Jardine
Jenilee Guebert
Tania Bubela
International Journal of Circumpolar Health, vol. 72, Supplement 1, 2013, p. article no. 21351
Description
Research agreements must be structured to ensure mutual benefits which reflect the equal status of both parties.
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Actinic Prurigo: Clinical Features and HLA Associations in a Canadian Inuit Population

Articles » Scholarly, peer reviewed
Author/Creator
Marni C. Wiseman
Pamela H. Orr
Sharon M. Macdonald
Marlis L. Schroeder
John W. P. Toole
Journal of the American Academy of Dermatology, vol. 44, no. 6, June 2001, pp. 952-956
Description
Conclusions indicated that AP in the Inuit is a seasonal photodermatitis which often commences in adulthood and worsens over time. Study found a novel HLA association.
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Activists and Scientists Clash Over Genome Project

Articles » General
Author/Creator
Fiona Muldrew
Herizons , vol. 10, no. 3, Summer, 1996, pp. 10-11
Description
Reports on Aboriginal activists lobbing to restrict genetic research on Indigenous cell lines as part of the International Human Genome Diversity Project in Winnipeg, Manitoba.
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Admixture in Mexico City: Implications For Admixture Mapping of Type 2 Diabetes Genetic Risk Factors

Articles » Scholarly, peer reviewed
Author/Creator
Veronica L. Martinez-Marignac
Adan Valladares
Emily Cameron
Andrea Chan
Arjuna Perera
et al.
Human Genetics, vol. 120, no. 6, 2007, pp. 807-819
Description
Discusses admixture mapping, a method which is used to identify genetic risk factors in complex diseases such as Type 2 diabetes between major continental groups.
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The Alaska Area Specimen Bank: A Tribal-Federal Partnership to Maintain and Manage a Resource for Health Research

Articles » Scholarly, peer reviewed
Author/Creator
Alan J. Parkinson
Thomas Hennessy
Lisa Bulkow
H. Sally Smith
Alaska Area Specimen Bank Working Group
International Journal of Circumpolar Health, vol. 72, 2013, p. article no. 20607
Description
Reports how the Alaska Area Specimen Bank (AASB) is a valuable resource and can be used to assess early markers for illness and disease.
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Albumin Naskapi: A New Variant of Serum Albumin

Articles » Scholarly, peer reviewed
Author/Creator
Liisa Melartin
B. S. Blumberg
Science, vol. 153, no. 3744, New Series, September 30, 1966, pp. 1664-1666
Description
Studies gene found in high-frequency in the Naskapi people of Quebec.
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Albumin Naskapi Variant in North American Indians and Eti Turks

Articles » Scholarly, peer reviewed
Author/Creator
Samuel G. Franklin
Susan I. Wolf
Yuksel Ozdemir
Gunes T. Yuregir
Turgay Isbir
Baruch S. Blumberg
Proceedings of the National Academy of Sciences of the United States of America, vol. 77, no. 9, September 1980, pp. 5480-5482
Description
Studies relationship of genetic consistency between the Naskapi of Quebec and the Eti Turks of Turkey
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American Indian and Alaska Native Genetics Research Resource Guide: Tools for Tribal Leaders and Citizens

E-Books » Documents & Presentations
Author/Creator
National Congress of American Indians Policy Research Center
[LeManuel Lee Bitsoi
Jessica Bardill
Lynne T. Bemis
Linda Burhansstipanov ... [et al.]
Description
Sections include: frequently asked questions, summary tools, basics of genetics, decisions about research, case studies, regulating research, and use of DNA for purposes of determining tribal enrollment.
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American Indian Genes in the Media: Representations of the Havasupai Indian Tribe in Their Case against Arizona State University

Articles » Scholarly, peer reviewed
Author/Creator
Raymond I. Orr
Justin Reedy
Dalaki Livingston
Paul Spicer
American Indian Culture and Research Journal, vol. 45, no. 2, 2021, pp. 65-80
Description
Discusses the media's framing of the Havasupai case against the Arizona State University's genomic research as a matter of ethics rather than an issue of Indigenous sovereignty.
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Amerindian Pyruvate Carboxylase Deficiency is Associated With Two Distinct Missense Mutations

Articles » Scholarly, peer reviewed
Author/Creator
Mary Anna Carbone
Nevi MacKay
Mingfu Ling
David E. C. Cole
Cheryl Douglas
Brigitte Rigate ... [et al.]
American Journal of Human Genetics, vol. 62, no. 6, June 1998, pp. 1312-1319
Description
Findings provide the first characterization of the human pyruvate carboxylase gene structure, identify common pathogenic mutations, as well as demonstrate founder effect in the study's Ojibwa and Cree patients.
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Analysis of HLA Class I and Class II in Na-Dene and Amerindian Populations From British Columbia, Canada

Articles » Scholarly, peer reviewed
Author/Creator
Maria Victoria Monsalve
Glenn Edin
Dana V. Devine
Human Immunology, vol. 59, no. 1, January 1998, pp. 48-55
Description
Genetic testing results suggest that Amerindian and Na-Dene populations have separate origins and are compatible with previous studies indicating the two populations are derived from different migrations from Asia.
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Analysis of Mitochondrial DNA Diversity in the Aleuts of the Commander Islands and its Implications for the Genetic History of Beringia

Articles » Scholarly, peer reviewed
Author/Creator
Olga A. Derbeneva
Rem I. Sukernik
Natalia V. Volodko
Seyed H. Hosseini
Marie T. Lott
Douglas C. Wallace
American Journal of Human Genetics, vol. 71, no. 2, August 2002, pp. 415-421
Description
DNA study that supports the theory that the founding Eskimo/Aleut peoples originated in Alaska.
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Ancient DNA Methodology: Thoughts from Brian M. Kemp and David Glenn Smith on "Mitochondrial DNA of Protohistoric Remains of an Arikara Population from South Dakota"

Articles » Scholarly, peer reviewed
Author/Creator
Brian M. Kemp
David Glenn Smith
Human Biology, vol. 82, no. 2, April 2010, pp. 227-238
Description
Discusses the classical stringent standards to retrieve and authenticate DNA from ancient remains and puts forth recommendations for future discoveries and progression of the ancient DNA field.
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Ancient DNA Studies and New Bioethic Problems

Articles » Scholarly, peer reviewed
Author/Creator
C. Lalueza Fox
Human Evolution, vol. 12, no. 4, October 1997, pp. 287-290
Description
Discussion of how new techniques allow genetics of extinct populations to be studied but raise ethical questions about using museum collections to gather samples.
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Are the Circumpolar Inuit Becoming Obese?

Articles » Scholarly, peer reviewed
Author/Creator
T. K. Young
American Journal of Human Biology, vol. 19, no. 2, 2007, pp. 181-189
Description
Discussion of the higher risk for obesity, the need for ethnospecific obesity criteria and health interventions.
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Association Between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a non-Caucasian Multi-Ethnic Sample

Articles » Scholarly, peer reviewed
Author/Creator
Salam A. Al-Attar
Rebbecca L. Pollex
Matthew R. Ban
T. Kue Young
Peter Bjerregaard... [et al.]
Cardiovascular Diabetology, vol. 7, no. 5, March 2008, p. 5
Description
Study results of Canadians of South Asian and Chinese descent, Oji-Cree and Inuit (Greenland) indicated that the association between FTO gene associated with obesity extends to non-Caucasian subjects.
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Autosomal Linkage Between the Albumin and Gc Loci in Humans

Articles » Scholarly, peer reviewed
Author/Creator
E. Kaarsalo
Liisa Melartin
B. S. Blumberg
Science, vol. 158, no. 3797, October 1967, pp. 123-125
Description
Using family material from the Naskapi and Montagnais Indians of the Labrador peninsula, the authors found evidence for close linkage between the loci that determine the two inherited traits.
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Biocultural Community Protocols: Dialogues on the Space Within

Articles » Scholarly, peer reviewed
Author/Creator
Sanjay Kabir Bavikatte
Daniel Francis Robinson
Maria Julia Oliva
IK: Other Ways of Knowing, vol. 1, no. 2, 2015, pp. 1-31
Description
Looks at the success or failure of laws and policies that were meant to protect community rights, culture, and material resources and the use of community protocols as tools.
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Biological Relationships among the Iroquois

Articles » Scholarly, peer reviewed
Author/Creator
Stephen P. Langdon
Human Biology, vol. 67, no. 3, June 1995, pp. 355-374
Description
Examines the differences found in Iroquois and Algonquians to determine the genetic drift between them.
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Birth Defects: Everyone's Concern

Articles » General
Author/Creator
Peter Gebadi
John Rae
Aboriginal and Islander Health Worker Journal, vol. 15, no. 3, May/June 1991, p. 5
Description
Brief description of one day workshop, An Introduction to Medical Genetics attended by Aboriginal health officers.
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The Blood Groups and Other Features of the Micmac Indians

Alternate Title
The Blood Groups and Other Features of the Mi'kmaq Indians
Articles » Scholarly, peer reviewed
Author/Creator
R. Ruggles Gates
Journal of the Royal Anthropological Institute of Great Britain and Ireland, vol. 68, July-December 1938, pp. 283-298
Description
Discusses blood types and genetic factors of Shubenacadie children in Nova Scotia.
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Blood Groups of the Naskapi and Montagnais Indians of Schefferville, Quebec

Articles » Scholarly, peer reviewed
Author/Creator
Baruch S. Blumberg
John R. Martin
Fred H. Allen
Judith L. Weiner
Elaine M. Vitagliano
Alan Cooke
Human Biology, vol. 36, no. 3, September 1964, pp. 263-272
Description
Findings indicate that the two groups appear to have significantly different gene pools with respect to some blood groups which would consider them distinct sub-populations.
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Blood, Lies, and Indian Rights: TCUs Becoming Gatekeepers for Research

Articles » General
Author/Creator
Juan A. Avila Hernandez
Tribal College Journal of American Indian Higher Education, vol. 16, no. 2, Tribal College Research, Winter, 2004
Description
Exposes an incident where 200 people gave blood to aid research into their diabetes epidemic; the samples were also used to do research into Havasupai genes and schizophrenia, inbreeding, and the Bering Strait theory without their consent. The Havasupai people filed a lawsuit against the Arizona State University for intentional deception.
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Bone Marrow Transplantation For T¯B¯ Severe Combined Immunodeficiency Disease [SCIDA] in Athabascan-Speaking Native Americans

Articles » Scholarly, peer reviewed
Author/Creator
A.S. O'Marcaigh
K. DeSantes
D Hu
H. Pabst
B. Horn
L. Li
M.J. Cowan
Bone Marrow Transplantation, vol. 27, no. 7, April 1, 2001, pp. 703-709
Description
Report examines treatment on 18 Navajo and Dene children with SCIDA. Findings demonstrate the efficacy of bone marrow transplantation when treating infants with this distinct form of SCID and indicates those who were treated with immunosuppressive and myeloablative therapy had a poor outcome.
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A BRCA1 Mutation in Native North American Families

Articles » Scholarly, peer reviewed
Author/Creator
Alexander Liede
Elaine Jack
Robert A. Hegele
Steven A. Narod
Human Mutation, vol. 19, no. 4, April 2002, pp. 460-[463]
Description
Study, which reports on two families with the same BRCA1 mutation, finds the first evidence of a BRCA1 mutation that is specific to North American aboriginal people.
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Brief Communication: Molecular Analysis of the Kwäday Dän Ts'finchi Ancient Remains Found in a Glacier in Canada

Articles » Scholarly, peer reviewed
Author/Creator
M. Victoria Monsalve
Anne C. Stone
Cecil M. Lewis
Allan Rempel
Michael Richards
Dan Straathof
Dana V. Devine
American Journal of Physical Anthropology, vol. 119, no. 3, November 2002, pp. 288-291
Description
Results revealed the remains share an mtDNA type with North American, Central American and South American populations.
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Canadian Native Indians Exhibit Unique CYP2A6 and CYP2C19 Mutant Allele Frequencies

Articles » Scholarly, peer reviewed
Author/Creator
Maciej P. Nowak
Edward M. Sellers
Rachel F. Tyndale
Clinical Pharmacology and Therapeutics , vol. 64, no. 4, October 1998, pp. 378-383
Description
Study findings indicate that Canadian Aboriginal subjects differ from both Asian and Caucasian genotype patterns for these mutant alleles, which may have consequences for clinical drug use among Canadian Aboriginals.
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